ヤクルト本社
プロバイオティクス・シンバイオティクスの情報サイト

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日本外科感染症学会「消化器外科SSI予防のための周術期管理ガイドライン2025」が公開されました。

2025年10月9日

外科感染症学会より、術前処置の一つとして、プロバイオティクス・シンバイオティクスの有用性が提案されました。
また、当該ガイドライにおけるシンバイオティクスの研究ではヤクルト本社との共同研究が引用されています。

是非ご確認ください。

ご不明な点は、弊社担当者までお問い合わせください。

共同研究の一覧はこちら

  • Yokoyama Y, Mizuno T, Sugawara G, et al.:Profile of preoperative fecal organic acids closely predicts the incidence of postoperative infectious complications after major hepatectomy with extrahepatic bile duct resection: Importance of fecal acetic acid plus butyric acid minus lactic acid gap. Surgery 2017;162:928-936. PMID:28684159.
  • Yokoyama Y, Miyake T, Kokuryo T, et al.:Effect of perioperative synbiotic treatment on bacterial translocation and postoperative infectious complications after pancreatoduodenectomy. Dig Surg 2016;33:220-229. PMID:26990315.
  • Komatsu S, Sakamoto E, Norimizu S, et al.:Efficacy of perioperative synbiotics treatment for the prevention of surgical site infection after laparoscopic colorectal surgery:
    A randomized controlled trial. Surg Today 2016;46:479-490. PMID:25933911.
  • Nishigaki E, Abe T, Yokoyama Y, et al.:The detection of intraoperative bacterial translocation in the mesenteric lymph nodes is useful in predicting patients at high risk for postoperative infectious complications after esophagectomy. Ann Surg 2014;259:477-484. PMID:23549427.
  • Yokoyama Y, Nishigaki E, Abe T, et al.:Randomized clinical trial of the effect of perioperative synbiotics versus no synbiotics on bacterial translocation after oesophagectomy.
    Br J Surg 2014;101:189-199. PMID:24402842.
  • Okazaki M, Matsukuma S, Suto R, et al.:Perioperative synbiotic therapy in elderly patients undergoing gastroenterological surgery: A prospective, randomized control trial.
    Nutrition 2013;29:1224-1230. PMID:23867209.
  • Tanaka K, Yano M, Motoori M, et al.:Impact of perioperative administration of synbiotics in patients with esophageal cancer undergoing esophagectomy: A prospective randomized controlled trial. Surgery 2012;152:832-842. PMID:22503510.
  • Eguchi S, Takatsuki M, Hidaka M, et al.:Perioperative synbiotic treatment to prevent infectious complications in patients after elective living donor liver transplantation:
    A prospective randomized study. Am J Surg 2011;201:498-502. PMID:20619394.
  • Usami M, Miyoshi M, Kanbara Y, et al.:Effects of perioperative synbiotic treatment on infectious complications, intestinal integrity, and fecal flora and organic acids in hepatic surgery with or without cirrhosis. JPEN J Parenter Enteral Nutr 2011;35:317-328. PMID:21527594.
  • Sugawara G, Nagino M, Nishio H, et al.:Perioperative synbiotic treatment to prevent postoperative infectious complications in biliary cancer surgery: A randomized controlled trial.
    Ann Surg 2006;244:706-714. PMID:17060763.
  • Kanazawa H, Nagino M, Kamiya S, et al.:Synbiotics reduce postoperative infectious complications: A randomized controlled trial in biliary cancer patients undergoing hepatectomy.
    Langenbecks Arch Surg 2005;390:104-113. PMID:15711820.